The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90β gene by interleukin-6 but have opposite effects on its inducibility by heat shock
نویسندگان
چکیده
*Department of Molecular Pathology, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London W1P 6DB, U.K., †Department of Medicine, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London W1P 6DB, U.K., ‡Medical School, Department of Biochemistry, Hyogo College of Medicine, 11 Mukogawa-Cho, Nishinomiya, Hyogo 663, Japan, and §Institute for Molecular and Cellular Biology, Osaka University, 1–3 Yamada-oka, Suita, Osaka 565, Japan
منابع مشابه
Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3-dependent manner.
Cervical carcinoma cells producing high levels of interleukin-6 (IL-6) were shown to be unresponsive to the cytokine IL-6 due to the loss of their IL-6 receptor. Addition of IL-6 receptor in a soluble form restores IL-6 signalling in SW756 carcinoma cells. This leads to a rapid and strong activation of the transcription factor signal transducer and activator of transcription 3 (STAT3). Nuclear ...
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تاریخ انتشار 1998